The Zoological Research Museum Alexander Koenig

is a research museum of the Leibniz Association

Dissection of Arp2/3 complex function and regulation in actin-based protrusion

Date: 
Mon, 11/16/2020 - 5:00pm
Meeting point: 
Lectures by Zoom Meetings. Links will be provided before talks
Event type: 
Lecture
Event series: 
Colloquium on evolution and biodiversity
Target group: 
Studierende
Lecturer: 
Prof. Dr. Klemens Rottner, Technische Universität Braunschweig

In higher eukaryotes, the formation of branched actin filament networks generated by Arp2/3 complex is crucial to a plethora of cellular processes, like cell edge protrusion, cell-cell adhesion, phagocytosis or membrane trafficking. We are dissecting the molecular regulation of these and related processes such as host-pathogen interaction using CRISPR/Cas9-mediated genome editing. We are characterizing derived, mutant cell lines with respect to essential, functional parameters and including various, advanced imaging approaches.

In this talk, I will focus on the molecular regulation of lamellipodium protrusion, and provide examples for how CRISPR/Cas9-edited cell lines can be employed to study the biochemistry, individual mutations or the gene dose of selected, Arp2/3 complex-dependent actin assembly complexes.

Contact person

Head of Section
+49 228 9122-241
+49 228 9122-295
h.waegele [at] leibniz-zfmk.de

Colloquium on biology

Prof. Dr. H. Wägele
Zoological Research Museum Alexander Koenig,
Adenauerallee 160, 53113 Bonn, Germany
 
Prof. Dr. G. von der Emde
Institute of Zoology, Poppelsdorfer Schloss,
Meckenheimer Allee 169, 53115 Bonn, Germany

Place: Great lecture hall, Poppelsdorfer Schloß
Time: mondays, 17.15 h

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