Das Zoologische Forschungsmuseum Alexander Koenig

ist ein Forschungsmuseum der Leibniz Gemeinschaft

Dissection of Arp2/3 complex function and regulation in actin-based protrusion

Termin: 
Mo, 16.11.2020 - 17:00 Uhr
Treffpunkt: 
Lectures by Zoom Meetings. Links will be provided before talks
Veranstaltungsart: 
Vortrag
Veranstaltungsreihe: 
Evolutionsbiologisches Kolloquium
Zielgruppe: 
Studierende
Vortragende / Vortragender: 
Prof. Dr. Klemens Rottner, Technische Universität Braunschweig

In higher eukaryotes, the formation of branched actin filament networks generated by Arp2/3 complex is crucial to a plethora of cellular processes, like cell edge protrusion, cell-cell adhesion, phagocytosis or membrane trafficking. We are dissecting the molecular regulation of these and related processes such as host-pathogen interaction using CRISPR/Cas9-mediated genome editing. We are characterizing derived, mutant cell lines with respect to essential, functional parameters and including various, advanced imaging approaches.

In this talk, I will focus on the molecular regulation of lamellipodium protrusion, and provide examples for how CRISPR/Cas9-edited cell lines can be employed to study the biochemistry, individual mutations or the gene dose of selected, Arp2/3 complex-dependent actin assembly complexes.

Ansprechpartnerin / Ansprechpartner

Sektionsleiterin
+49 228 9122-241
+49 228 9122-295
h.waegele [at] leibniz-zfmk.de

Biologisches Kolloquium

Prof. Dr. H. Wägele
Zoologisches Forschungsmuseum Alexander Koenig,
Adenauerallee 160, 53113 Bonn
 
Prof. Dr. G. von der Emde
Institut für Zoologie, Poppelsdorfer Schloss,
Meckenheimer Allee 169, 53115 Bonn
 
Ort: Großer Hörsaal, Poppelsdorfer Schloß
Zeit: montags, 17.15 Uhr
 

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