The Zoological Research Museum Alexander Koenig

is a research museum of the Leibniz Association

The role of ubiquitin ligase APC/C in regulating the meiotic cell cycle

Date: 
Mon, 05/20/2019 - 5:15pm
Meeting point: 
Poppelsdorfer Schloss
Location: 
Lecture hall
Event type: 
Lecture
Event series: 
Colloquium on evolution and biodiversity
Target group: 
Studierende
Lecturer: 
Prof. Dr. Thomas U. Mayer, University of Konstanz

The meiotic cell cycle is unique in that it involves two M phases with no intervening S phase. A peculiar characteristic of female meiosis in vertebrates is that oocytes undergo distinct cell cycle arrests: immature oocytes arrest at prophase at meiosis I and following meiotic maturation they arrest as mature oocytes again at metaphase of meiosis II.

The prophase I arrest of immature oocytes – which belongs to the longest known cell cycle arrests – is released by hormonal stimulation, while the MII arrest of mature oocytes is released by fertilization.

Our research aims at a better understanding of how the interplay of reversible protein phosphorylation and selective destruction by the ubiquitin-proteasome pathway controls the MI and MII arrest of oocytes and the release of oocytes from these arrest stages.

Contact person

Head of Section
+49 228 9122-241
+49 228 9122-295
h [dot] waegele [at] zfmk [dot] de

Colloquium on biology

Prof. Dr. H. Wägele
Zoological Research Museum Alexander Koenig,
Adenauerallee 160, 53113 Bonn, Germany
 
Prof. Dr. G. von der Emde
Institute of Zoology, Poppelsdorfer Schloss,
Meckenheimer Allee 169, 53115 Bonn, Germany

Place: Great lecture hall, Poppelsdorfer Schloß
Time: mondays, 17.15 h

Events

Mo Tu We Th Fr Sa Su
 
 
1
 
2
 
3
 
4
 
5
 
 
7
 
8
 
9
 
10
 
11
 
12
 
13
 
14
 
15
 
16
 
17
 
18
 
19
 
 
21
 
22
 
23
 
24
 
25
 
26
 
 
28
 
29
 
30
 
31