The Zoological Research Museum Alexander Koenig

is a research museum of the Leibniz Association

Central Nervous System Ventralization

Date: 
Mon, 10/14/2019 - 5:00pm
Meeting point: 
Poppelsdorfer Schloss
Location: 
Lecture hall
Event type: 
Lecture
Event series: 
Colloquium on evolution and biodiversity
Target group: 
Studierende
Lecturer: 
PD Dr. Mario Wullimann, Ludwig-Maximilians-University, Munich

Ventralization, a major patterning process in developing vertebrate central nervous systems, depends on Sonic hedgehog (Shh) as a main signaling morphogen.

As expected, this gene is expressed in the zebrafish brain in ventrally located floor plate cells of spinal cord and brainstem floor plate. Further, a ventral telencephalic Shh domain is newly identified in zebrafish known to be important for correct basal ganglia development in land-vertebrates (e.g. mammals and birds).

Also, posterior forebrain zebrafish dopamine cells projecting into the basal ganglia derive directly from Shh expressing cells (as do mammalian substantia nigra/ventral tegmental cells affected in Parkinson’s disease in humans).

Contact person

Head of Section
+49 228 9122-241
+49 228 9122-295
h.waegele [at] leibniz-zfmk.de

Colloquium on biology

Prof. Dr. H. Wägele
Zoological Research Museum Alexander Koenig,
Adenauerallee 160, 53113 Bonn, Germany
 
Prof. Dr. G. von der Emde
Institute of Zoology, Poppelsdorfer Schloss,
Meckenheimer Allee 169, 53115 Bonn, Germany

Place: Great lecture hall, Poppelsdorfer Schloß
Time: mondays, 17.15 h

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