The Zoological Research Museum Alexander Koenig

is a research museum of the Leibniz Association

Bactofilins: a new and versatile class of cytoskeletal proteins in bacteria

Date: 
Mon, 05/06/2019 - 5:00pm
Meeting point: 
Poppelsdorfer Schloss
Location: 
Lecture hall
Event type: 
Lecture
Event series: 
Colloquium on evolution and biodiversity
Target group: 
Studierende
Lecturer: 
Prof. Dr. Martin Thanbichler Max Planck Institute for Terrestrial Microbiolology, Faculty of Biology, Philipps-Universität, and LOEWE Center for Synthetic Microbiology, Marburg, Germany

In recent years, it has become evident that bacteria contain various cytoskeletal proteins that are critical for their fitness and survival. These include homologs of actin, tubulin and intermediate fila­ment proteins as well as bacteria-specific factors, such as the bactofilins.

Bactofilins are an atypical group of cytoskeletal proteins that share structural simililarity with prion pro­teins and assemble into stable polymeric structures without the need for nucleotide cofactors. They are almost ubiquitous among bacteria and often present in multiple paralogous copies per species, suggesting that they have critical cellular functions. However, their biological roles and polymer­ization behavior remain poorly understood.

This talk will highlight recent structural and functional studies on the physiological roles of bactofilin polymers in selected bacterial model organisms. The results obtained show that bactofilins serve as multi-purpose cytoskeletal scaffolds that recruit inter­acting proteins to the (sub)polar regions of the cell, thereby controlling a range of different pathways. This functional divergence underscores the diversity of mechanisms that control the spatiotemporal organization of bacteria.

Contact person

Head of Section
+49 228 9122-241
+49 228 9122-295
h.waegele [at] leibniz-zfmk.de

Colloquium on biology

Prof. Dr. H. Wägele
Zoological Research Museum Alexander Koenig,
Adenauerallee 160, 53113 Bonn, Germany
 
Prof. Dr. G. von der Emde
Institute of Zoology, Poppelsdorfer Schloss,
Meckenheimer Allee 169, 53115 Bonn, Germany

Place: Great lecture hall, Poppelsdorfer Schloß
Time: mondays, 17.15 h

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