Das Zoologische Forschungsmuseum Alexander Koenig

ist ein Forschungsmuseum der Leibniz Gemeinschaft

The role of ubiquitin ligase APC/C in regulating the meiotic cell cycle

Termin: 
Mo, 20.05.2019 - 17:15 Uhr
Treffpunkt: 
Poppelsdorfer Schloss
Ort: 
Hörsaal
Veranstaltungsart: 
Vortrag
Veranstaltungsreihe: 
Evolutionsbiologisches Kolloquium
Zielgruppe: 
Studierende
Vortragende/r: 
Prof. Dr. Thomas U. Mayer, Universität Konstanz

The meiotic cell cycle is unique in that it involves two M phases with no intervening S phase. A peculiar characteristic of female meiosis in vertebrates is that oocytes undergo distinct cell cycle arrests: immature oocytes arrest at prophase at meiosis I and following meiotic maturation they arrest as mature oocytes again at metaphase of meiosis II.

The prophase I arrest of immature oocytes – which belongs to the longest known cell cycle arrests – is released by hormonal stimulation, while the MII arrest of mature oocytes is released by fertilization.

Our research aims at a better understanding of how the interplay of reversible protein phosphorylation and selective destruction by the ubiquitin-proteasome pathway controls the MI and MII arrest of oocytes and the release of oocytes from these arrest stages.

Ansprechpartner

Sektionsleiterin
+49 228 9122-241
+49 228 9122-295
h [dot] waegele [at] zfmk [dot] de

Biologisches Kolloquium

Prof. Dr. H. Wägele
Zoologisches Forschungsmuseum Alexander Koenig,
Adenauerallee 160, 53113 Bonn
 
Prof. Dr. G. von der Emde
Institut für Zoologie, Poppelsdorfer Schloss,
Meckenheimer Allee 169, 53115 Bonn
 
Ort: Großer Hörsaal, Poppelsdorfer Schloß
Zeit: montags, 17.15 Uhr
 

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